Understanding how drinking disrupts your gut-brain axis and circadian rhythm Alcohol does more than give you a buzz — it directly affects your gut microbiome , your sleep architecture , and even your mood  the next day. These systems are all linked through the gut-brain axis , a communication network connecting your digestive tract, nervous system, hormones, and immune signaling. If you’ve ever wondered why alcohol leaves you bloated, anxious, or exhausted, this guide breaks